Li, Xiuze published the artcileParecoxib sodium pretreatment reduces myoclonus after etomidate: a prospective, double-blind, randomized clinical trial, Category: isoxazole, the publication is International Journal of Clinical Pharmacology and Therapeutics (2017), 55(7), 601-605, database is CAplus and MEDLINE.
Objective: Myoclonus induced by etomidate during induction of general anesthesia is a common phenomenon. This prospective, randomized, saline-controlled clin. study was performed to evaluate the effect of parecoxib sodium pretreatment on the incidence and severity of etomidate induced myoclonus. Methods: 60 patients, American Society of Anesthesiologists (ASA) phys. status I or II, aged 20 to 60 years, who were scheduled to undergo elective laparoscopic cholecystectomy under general anesthesia, were allocated randomly into one of two groups to receive parecoxib sodium 40 mg i.v. (group P, n = 30) or the same volume of saline (group S, n = 30) 30 min before administration of etomidate (0.3 mg/kg). Myoclonus was assessed on a scale of 0 – 3. Postoperative side effects were recorded. Results: The two groups were comparable with regard to baseline characteristics. The incidence of myoclonus was significantly lower in the parecoxib sodium group (11/30; 37%) than in the saline group (21/30; 70%) (p < 0.05). The severity of myoclonic movements was also significantly reduced by parecoxib sodium (p < 0.05). There were no significant differences between the two groups with respect to postoperative side effects. Conclusions: Pretreatment with i.v. injection of parecoxib sodium 40 mg significantly reduced the incidence and severity of etomidate- induced myoclonus without significant side effects.
International Journal of Clinical Pharmacology and Therapeutics published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Category: isoxazole.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem