Li, Li-biao published the artcileComparison of pain thresholds and analgesic effects of parecoxib sodium in surgical patients of different racial and religious backgrounds, Synthetic Route of 198470-85-8, the publication is Zhongguo Yixue Kexueyuan Xuebao (2015), 37(3), 325-330, database is CAplus and MEDLINE.
The aim is to explore the differences of pain thresholds and analgesic effects of parecoxib sodium among patients with different racial and religious backgrounds. A total of 48 male patients aged 18 to 38 years who had undergone elective laparoscopic appendectomy under general anesthesia in our center were enrolled in our study, and then divided into 6 groups(n=8 in each group) based on their racial backgrounds(three levels: Mongoloid, Negroid, and Europoid) and religious backgrounds(two levels: without religion background, with religion background). All subjects received same anesthesia, surgical procedure, and postoperative analgesia with parecoxib sodium. The temperature pain threshold and elec. pain threshold were detected 1 h before and after analgesia. The threshold of pain was higher in Europoids than that in Negroids and Mongoloids before and after treatment. The temperature pain threshold and elec. pain threshold were not significantly different between subjects with or without religious background(before analgesic therapy: F=251.119, P=0.130, F=275.861, P=0.059; after analgesic therapy: F=308.531, P=0.086, F=180.062, P=0.078). Also, there was no interaction between the racial and religious backgrounds in terms of temperature pain threshold and elec. pain threshold(F=13.553, P=0.091, F=22.001, P=0.089; after analgesic therapy: F=4.624, P=0.089, F=15.935, P=0.094). The threshold of pain differed among individuals with different racial background, and it was the highest in Europoids, followed by Negroids and Mongoloids. It showed no obvious difference in people with different religious backgrounds.
Zhongguo Yixue Kexueyuan Xuebao published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Synthetic Route of 198470-85-8.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem