Radical difluoromethylthiolation of aromatics enabled by visible light was written by Li, Jianbin;Zhu, Dianhu;Lv, Leiyang;Li, Chao-Jun. And the article was included in Chemical Science in 2018.Product Details of 59669-59-9 This article mentions the following:
An efficient route to access a valuable catalog of difluoromethyl thioethers RSCHF2 [R = 1-Me-2-pyrrolyl, 3-indolyl, 2,4,6-(MeO)3C6H2, etc.] via visible-light mediated direct introduction of a difluoromethylthio group (-SCF2H) to arenes RH under metal-free and mild conditions was reported. This light-mediated protocol successfully converted a broad spectrum of arenes and heteroarenes to difluoromethyl thioethers in the absence of noble metals and stoichiometric amounts of additives. In the experiment, the researchers used many compounds, for example, 3-(tert-Butyl)isoxazol-5-amine (cas: 59669-59-9Product Details of 59669-59-9).
3-(tert-Butyl)isoxazol-5-amine (cas: 59669-59-9) belongs to isoxazole derivatives. An isoxazolyl group is found in many beta-lactamase-resistant antibiotics, such as cloxacillin, dicloxacillin and flucloxacillin. Isoxazoles are potent isosteres of pyridine and have been found to inhibit voltage-gated sodium channels for pain control, for the construction of tetracycline antibiotic derivatives, and as a therapeutic agent for depression.Product Details of 59669-59-9
Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem