Li, Jian-yu published the artcileEffects of dexmedetomidine on postoperative mechanical pain threshold in patients undergoing laparoscopic cholecystectomy under continuous infusion of remifentanil, Quality Control of 198470-85-8, the publication is Shiyong Yixue Zazhi (2015), 31(21), 3574-3577, database is CAplus.
This paper is to identify whether dexmedetomidine can prevent postoperative hyperalgesia of patients undergoing laparoscopic cholecystectomy. One hundred and twenty patients undergoing elective laparoscopic cholecystectomy were randomly divided into three groups: dexmedetomidine group (group D, patients receiving dexmedetomidine), parecoxib sodium group (group P, patients receiving parecoxib sodium) and control group (group C). Mech. pain thresholds on periincisional area and VAS score were recorded 2, 4, 8, 12, 24, 48 h after surgery. Mech. pain thresholds in group C at 2, 4, 8, 12, 24, 48 h after operation decreased significantly compared with those before operation(P<0.01) but those in group D had no significant difference, and the thresholds in group P at 4 h, 8 h had no significant decrease. Compared with those in group C, mech. pain thresholds in group D increased at 2, 4, 8, 12, 24, 48 h after operation(P<0.05), and those in group P increased at 4 h and 8 h after operation(P<0.05). Compared with those in group P, mech. pain thresholds in group D increased at 12, 24, 48 h after operation. Compared with preoperative VAS values, values were significantly increased in every group(P<0.05). Furthermore, postoperative VAS values had no correlation with mech. pain threshold in each group and the incidence of adverse reactions had no significant difference among three groups(P>0.05). Dexmedetomidine can prevent postoperative hyperalgesia in patients undergoing laparoscopic cholecystectomy.
Shiyong Yixue Zazhi published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Quality Control of 198470-85-8.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem