Li, Dan published the artcileComparison of parecoxib sodium and flurbiprofen axetil in children undergoing endoscopic adenoidectomy and tonsillectomy, Computed Properties of 198470-85-8, the publication is Guoji Mazuixue Yu Fusu Zazhi (2014), 35(12), 1098-1100, 1108, database is CAplus.
The postoperative analgesia effect of parecoxib Na and flurbiprofen axetil in children undergoing endoscopic adenoidectomy and tonsillectomy was comparatively studied. Sixty children, aged 5-8 yr, scheduled for endoscopic adenoidectomy and tonsillectomy under general anesthesia were randomly divided into group A (parecoxib Na), group B(flurbiprofen axetil), group C (normal saline) (n=20). Parecoxib Na 1 mg/kg and flurbiprofen axetil 1 mg/kg were administered i.v. 15 min before the start of operation, meanwhile children in group C received normal saline. The extubation time, agitation occurrences, recovery period pain scores, remifentanil dose, and side effects were observed and compared. There was no difference between the three groups in operation time, extubation time, and remifentanil dose (P>0.05). The emergence of postoperative agitation was 5% in group A and group B, 55% in group C, which was significantly lower in group A and group B than in group C (P<0.01). The pain scores of group C were significantly higher than those in group A and group B (P<0.01). The emergence of nausea and vomiting was 5% in group C. Applying parecoxib Na and flurbiprofen axetil in children undergoing endoscopic adenoidectomy and tonsillectomy can provide a good analgesia effect, reduce postoperative agitation, and do not postpone the extubation time.
Guoji Mazuixue Yu Fusu Zazhi published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Computed Properties of 198470-85-8.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem