The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-Piperidineacetic Acid(SMILESS: OC(=O)CN1CCCCC1,cas:3235-67-4) is researched.Application In Synthesis of 3,5-Dimethyl-4-nitropyridine 1-oxide. The article 《Synthesis and pharmacological evaluation of glycine-modified analogues of the neuroprotective agent glycyl-L-prolyl-L-glutamic acid (GPE)》 in relation to this compound, is published in Bioorganic & Medicinal Chemistry. Let’s take a look at the latest research on this compound (cas:3235-67-4).
The synthesis of ten G*PE (H-Gly*-Pro-Glu-OH) analogs, wherein the glycine residue has been modified, is described by coupling readily accessible H-Pro-Glu(OCH2Ph)-OCH2Ph with various analogs of glycine. Pharmacol. evaluation of the novel peptides was undertaken to further understand the role of the glycine residue on the observed neuroprotective properties of the endogenous tripeptide GPE.
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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem