Lavanya, M. published the artcileSynthesis, crystal structure, DNA binding and antitumor studies of β-diketonate complexes of divalent copper, zinc and palladium, Related Products of isoxazole, the publication is Inorganica Chimica Acta (2018), 76-86, database is CAplus.
This paper reports a simple approach for the synthesis of three pairs of novel mononuclear β-diketonate complexes of copper(II), zinc(II) and palladium(II) from monobasic O-O donor ligands 3-phenyl-4-fluorobenzolyl-5-isoxazolone (HL1) and 3-phenyl-4-toluyl-5-isxoazolone (HL2). The synthesized compounds were characterized by FTIR, ESI/FAB mass, 1H NMR, UV-visible and thermogravimetric analyses. The free ligand HL1 and the copper(II) complex, [Cu(L2)2(CH3OH)2] are unambiguously characterized by single crystal x-ray diffraction studies. The free ligand HL1 has adopted orthorhombic crystal system with P2(1) space group and a 8.1552(3), b 10.1169(4), c 17.0819(6) à , and α = β = γ 90.°. The crystal structure of the complex, [Cu(L2)2(CH3OH)2] is monoclinic with P2(1)/c space group and a 10.2571(2), b 16.2640(3), c 20.1717(3) à , and α 90.β 99.56 and γ 90.°. The copper(II) complex has adopted distorted octahedral geometry where the z-axis is occupied by two solvent methanol mols. according to the crystal data. While the EPR spectra of both the Cu(II) complexes display a strong axial signal with gvbr â?2.2 and gbottom â?2.0, which obviously suggests the square planar geometry around the copper(II) ion. The interaction of the complexes with calf thymus DNA (CT-DNA) was studied using UV-visible and fluorescence spectroscopic techniques. Anticancer activity of the complexes revealed their potential towards inhibiting the growth of human breast cancer cell lines, MDA-MB-231. The palladium complexes of both the ligands are good in exhibiting apoptosis. Also, the complexes of fluoro-substituted ligand are better antimicrobial agents when compared with those of Me substituted ligand.
Inorganica Chimica Acta published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C9H7NO2, Related Products of isoxazole.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem