Stability and structure of transition metal complexes with azoles in aqueous solutions. Part XVIII. Comparison of complex-forming ability of pyrazoles, isothiazoles and isoxazoles was written by Kulig, Jacek;Lenarcik, Beniamin. And the article was included in Polish Journal of Chemistry in 1978.COA of Formula: C4H5NO This article mentions the following:
Stability constants were determined potentiometrically for isoxazole and isothiazole complexes of Co(II), Ni(II), Cu(II), Zn(II) and Ag(I) at a constant ionic strength (0.5; KNO3) at 25°. The stability of the azole complexes containing two hetero atoms at positions 1 and 2 of the heterocyclic ring is discussed. In the experiment, the researchers used many compounds, for example, 5-Methylisoxazole (cas: 5765-44-6COA of Formula: C4H5NO).
5-Methylisoxazole (cas: 5765-44-6) belongs to isoxazole derivatives. Isoxazoles also form the basis for a number of drugs, including the COX-2 inhibitor valdecoxib (Bextra) and a neurotransmitter agonist AMPA. Isoxazoles are potent isosteres of pyridine and have been found to inhibit voltage-gated sodium channels for pain control, for the construction of tetracycline antibiotic derivatives, and as a therapeutic agent for depression.COA of Formula: C4H5NO
Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem