Cycloserine and related compounds. XI. 4-Hydroxy-3– isoxazolidone and some of its derivatives was written by Khomutov, R. M.;Karpeiskii, M. Ya.;Chang, Chih-P’ing;Kochetkov, N. K.. And the article was included in Zhurnal Obshchei Khimii in 1960.HPLC of Formula: 80348-66-9 The following contents are mentioned in the article:
cf. CA 53, 9186e; 54, 21046c. Addition of 6.1 g. HONH2.H2SO4 at -5° to 6.8 g. NaOH in H2O, followed by 6.1 g. Me chloropropionate and stirring 4 hrs. finally at 20°, gave after standing 12 hrs. and treatment with MeOH, an unstated yield of 3-isoxazolidone isolated as Na salt hemihydrate decomposing 68°; monohydrate decomposed 61-2°. This with H2SO4 in MeOH gave 3-isoxazolidone decomposed 69-70°. Similarly were prepared: 4-hydroxy-3-isoxazolidone (I) m. 77° (Na salt decomposed 60-4°); 4-methoxy-3-isoxazolidone decomposed 78-9° (Na salt decomposed 65-8°); 4-ethoxy analog Na salt decomposed 68°; 4-acetoxy-3-isoxazolidone decomposed 91-2°. I hydrogenated over Pt in MeOH to glyceramide m. 91°. Keeping I in MeOH-dry HCl 24 hrs. gave glyceramide. Paper chromatographic Rf values for the products were determined This study involved multiple reactions and reactants, such as Isoxazol-4-ol (cas: 80348-66-9HPLC of Formula: 80348-66-9).
Isoxazol-4-ol (cas: 80348-66-9) belongs to isoxazole derivatives. Isoxazoles are aromatic heterocycles containing an N–O bond. The weakness of this bond allows the ring opening of these heterocycles under reductive conditions. Some alternative routes for the synthesis of isoxazoles have also been developed and reported. The 2-benzoyl-2-halo-2H-azirines provide 4-haloisoxazoles in good yields after heating in toluene at reflux temperature.HPLC of Formula: 80348-66-9
Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem