Kang, Kai published the artcileComparison of the analgesic effect of two kinds of non-steroidal analgesics on elderly gynecologic laparoscopic surgery and their impact on cognitive function, Synthetic Route of 198470-85-8, the publication is Beijing Yixue (2016), 38(11), 1160-1163, database is CAplus.
Objective To compare the analgesic effect of flurbiprofen and parecoxib sodium on gynecol. laparoscopic surgery for the elderly and their influence on cognitive function. Methods Elective laparoscopic surgery were preformed under endotracheal intubation general anesthesia in 80 elderly women. The patients were randomly divided into four groups: Group F1 was given flurbiprofen axetil 50 mg after intubation, Group F2 received flurbiprofen axetil 50 mg half an hour before the end of the surgery, and Group P1 was given parecoxib sodium 40 mg after intubation, group P2 received parecoxib sodium 40 mg half an hour before the end of the surgery; 20 patients in each group. All patients with general anesthesia induction and intraoperative, postoperative i.v. analgesia pump connecting the same recipe to anesthesia recovery room. HR, MAP at each time point were recorded, HR and MAP were recorded 6 h, 12 h and 24 h after anesthesia and VAS pain score, Ramsay sedation scores and Riker-SAS agitation score were recorded preoperatively and 24 h, 72 h and postoperatively to measure cognitive dysfunction. Results The VAS score 6 h after operation of F2 and P2 was significantly lower than F1 and P1 group (P<0.05), VAS score of the P1 and P2 group 12 h after surgery was lower than F1 and F2 group. Postoperative VAS score of the four groups was not statistically different at 24 h (P>0.05). Compared with 24 h preoperative, MMSE score in the four groups of patients 24 h postoperatively was decreased, the difference was statistically significant (P<0.05). Compared with F2 and P2 group, 24 h MMSE score of the F1 and P1 group was increased, the incidence of POCD within 72 h was lower (P<0.05). Conclusion These two non-steroidal analgesics can reduce the incidence of POCD, giving parecoxib sodium after intubation seems to be more reasonable for postoperative analgesia.
Beijing Yixue published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Synthetic Route of 198470-85-8.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem