Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 30165-96-9, Name is 3-Chloro-4-morpholino-1,2,5-thiadiazole, molecular formula is C6H8ClN3OS, belongs to Isoxazoles compound, is a common compound. In a patnet, author is Du Guangjian, once mentioned the new application about 30165-96-9, SDS of cas: 30165-96-9.
Synthesis and Antibacterial Activity of 3-(Morpholinopyridyl)-5-substituted Isoxazole Derivatives
A series of 3-(morpholinopyridyl)-5-substituted isoxazole derivatives were prepared starting from 6-chloropyridine-3-carbaldehyde. The structures of the products were confirmed by IR, NMR and MS data. The products have an isoxazole mother core with 3-morpholinopyridyl substitution and possess an approximately planar structure. In addition a number of ester groups, amino groups, triazole groups and oxazolidinone groups were introduced to 5-position of the isoxazole mother core. The antibacterial activities of the products against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, Staphylococcus epidermis, Enterococcus faecalis and Escherichia coli were studied. Inferior activities (MIC>32 mg/L) were observed in comparison with linezolid. The results imply that the lack of 5-sp(3) hybridization structure may result in the decrease of antibacterial activity of isoxazole derivatives.
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Reference:
Isoxazole – Wikipedia,
,Isoxazole | C3H3NO – PubChem