Design and synthesis of 3-(2-pyridyl)pyrazolo[1,5-a]pyrimidines as potent CRF1 receptor antagonists was written by Huang, Charles Q.;Wilcoxen, Keith M.;Grigoriadis, Dimitri E.;McCarthy, James R.;Chen, Chen. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2004.Electric Literature of C4H5NO This article mentions the following:
A series of 3-(2-pyridyl)pyrazolo[1,5-a]pyrimidines I [R1 = Cl, O2N, Me, F3C, H2N, HO, etc.; R2 = H, Me, Cl, O2N, H2N, MeO, NO, etc.; R3, R4 = n-Pr, n-Bu, MeOCH2CH2, cyclopropylmethyl, PhCH2] was designed and synthesized as antagonists for the corticotropin-releasing factor-1 (CRF1) receptor. Several compounds such as I [R1 = Me2N; R2 = Me; R3 = R4 = n-Pr; (II)] (Ki = 10 nM) exhibited good binding affinities at the CRF1 receptor. In addition, II had adequate solubility in water. In the experiment, the researchers used many compounds, for example, 5-Methylisoxazole (cas: 5765-44-6Electric Literature of C4H5NO).
5-Methylisoxazole (cas: 5765-44-6) belongs to isoxazole derivatives.Synthetically, isoxazoles serve as valuable precursors for the construction of diverse molecules, including many natural products. Isoxazoles are potent isosteres of pyridine and have been found to inhibit voltage-gated sodium channels for pain control, for the construction of tetracycline antibiotic derivatives, and as a therapeutic agent for depression.Electric Literature of C4H5NO
Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem