Hoang, Le Tuan Anh published the artcilePromising Anticancer Drug Candidates Based on the 7-methoxychromone Scaffold: Synthesis and Evaluation of Antiproliferative Activity, Recommanded Product: 3-Phenylisoxazol-5(2H)-one, the publication is Letters in Drug Design & Discovery (2015), 12(5), 385-392, database is CAplus.
A series of 18 chromone derivatives I [R = HCC(O)OCH2CH3, 2,4,6-trioxo-1,3-diazinan-5-yl, 5-oxo-3-phenyl-4,5-dihydro-1,2-oxazol-4-yl, 1,3-dioxo-2,3-dihydro-1H-inden-2-yl, piperidin-1-amine, etc.] were designed and synthesized from paeonol. All synthetic compounds I were evaluated for their anti-proliferative activity towards eight human cancer cell lines including HepG2, HL-60, KB, LLC, LNCaP, LU-1, MCF7, and SW480. The compounds I (R = 2,4,6-trioxo-1,3-diazinan-5-yl, 1,3-dimethyl-2,4,6-trioxo-1,3-diazinan-5-yl) presented the best cytotoxic effects towards tested cancer cell lines except HepG2. Their IC50 values were ranging from 7.9±0.4 to 18.9±1.3 μg/mL. Meanwhile, compound I (R = 2-imino-3-methyl-5-oxoimidazolidin-4-yl) showed selective cytotoxicity against MCF7 and KB with IC50 of 13.7±0.6 and 15.5±0.9 μg/mL, resp.
Letters in Drug Design & Discovery published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C9H7NO2, Recommanded Product: 3-Phenylisoxazol-5(2H)-one.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem