The influence of alkyl substituents on the chromatographic indicator of self-association of N-containing heterocyclic compounds was written by Golovnya, R. V.;Kuz’menko, T. E.;Krikunova, N. I.. And the article was included in Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya) in 2000.Category: isoxazole This article mentions the following:
The chromatog. indicator of the ability of substances to form associates in a pure liquid δTb.p. proposed in the authors’ previous study was used to estimate the capacity for self-association of alkyl-substituted imidazoles, pyrazoles, pyrroles, oxazoles, isoxazoles, pyridazines, pyrimidines, pyrazines, and pyridines. Alkyl substituents introduced in heterocyclic compounds decrease the δTb.p. values, which is consistent with the data on the heats of self-association of heterocyclic compounds in pure liquids The reasons for the difference between the b.p. of a compound at standard pressure and its gas-chromatog. b.p. are discussed. In the experiment, the researchers used many compounds, for example, 5-Methylisoxazole (cas: 5765-44-6Category: isoxazole).
5-Methylisoxazole (cas: 5765-44-6) belongs to isoxazole derivatives. Isoxazole are described as inhibitors of acetylcholinesterase (AChE). Isoxazole ligands bind to and inhibit the Sxc- antiporter. Isoxazoles are potent isosteres of pyridine and have been found to inhibit voltage-gated sodium channels for pain control, for the construction of tetracycline antibiotic derivatives, and as a therapeutic agent for depression.Category: isoxazole
Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem