21169-71-1, Name is Isoxazole-5-carboxylic acid, belongs to Isoxazoles compound, is a common compound. COA of Formula: C4H3NO3In an article, once mentioned the new application about 21169-71-1.
Sulfonyl-morpholino-pyrimidines: SAR and development of a novel class of selective mTOR kinase inhibitor
High throughput screening to identify inhibitors of the mTOR kinase revealed sulfonyl-morpholino-pyrimidine 1 as an attractive start point. The compound displayed good physicochemical properties and selectivity over related kinases such as PI3Kalpha. Library preparation of related analogs allowed the establishment of additional SAR understanding and in particular the requirement for a key hydrogen bond donor motif at the 4-position of the phenyl ring in compounds such as indole 19. Isosteric replacement of the indole functionality led to the identification of urea compounds such as 32 that show good levels of mTOR inhibition in both enzyme and cellular assays.
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Reference£º
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem