Final Thoughts on Chemistry for 5-(4-Hydroxyphenyl)isoxazole-3-carboxylic acid

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Related Products of 33282-15-4, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 33282-15-4, 5-(4-Hydroxyphenyl)isoxazole-3-carboxylic acid, introducing its new discovery.

Treatment of magnesium cyclopropylidenes, which were generated from 1-chlorocyclopropyl phenyl sulfoxides with isopropylmagnesium chloride in THF at -78 C, with N-lithio arylamines gave arylamines cyclopropylated at the 2-position in moderate to good yields. Use of the magnesium cyclopropylidenes having at least one substituent was found to be essential to this cyclopropylation. This procedure offers a novel synthesis of arylamines having a cyclopropane ring at the 2-position directly from arylamines.

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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem