So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Li, Chuan-chuan; Zheng, Zhan-chao; Zhou, Yan; Zhang, Chuan-hao; Zhan, Jia-rong researched the compound: 2-Chloropyridine 1-oxide( cas:2402-95-1 ).Safety of 2-Chloropyridine 1-oxide.They published the article 《Synthesis of ZPT as a broad-spectrum fungicide》 about this compound( cas:2402-95-1 ) in Huaxue Shiji. Keywords: ZPT preparation fungicide; chloropyridine oxidation thiolation. We’ll tell you more about this compound (cas:2402-95-1).
In the oxidation catalytic system of maleic anhydride and acetic acid, 2-chloropyridine is converted to ZPT as a raw material. Controlling the thiolation reaction by Na2S-NaSH buffer system, the overall yield is about 75%. The route is suitable for industrial production due to low cost, easy preparation, low risk and high yield.
There are many compounds similar to this compound(2402-95-1)Safety of 2-Chloropyridine 1-oxide. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.
Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem