Feinn, Liana published the artcileAntimicrobial Evaluation of 5-Substituted Aryl 1H-Tetrazoles, COA of Formula: C8H5F3N4, the publication is Medicinal Chemistry (Sharjah, United Arab Emirates) (2017), 13(4), 359-364, database is CAplus.
Tetrazole derivatives such as 1-substituted dinitrobenzyl tetrazoles and their oxa and selanyl analogs have previously been studied against drug-susceptible and multidrug-resistant mycobacteria. In addition, other tetrazole derivatives have been shown to inhibit CTX-M class A β-lactamases. We studied the antibacterial activity of 5-substituted aryl 1H-tetrazole derivatives The antibacterial activity of several known 5-substituted aryl 1H-tetrazole derivatives was evaluated against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. The activity was assessed by determining the min. inhibitory concentration of these tetrazole derivatives and comparing them to the known antibiotics amoxicillin, trimethoprim, and sulfamethoxazole. Some derivatives showed significant antibacterial activity with the most active derivatives exhibiting a min. inhibitory concentration (MIC) of 125-250 μg/mL against S. aureus and E. coli. Using some of these tetrazole compounds in combination with trimethoprim led to a synergistic effect that gave MIC values ranging from 0.24-1.95 μg/mL against E. coli and 3.91-31.3 μg/mL against S. aureus. The tetrazole derivatives were prepared in an isopropanol/water mixture using microwave heating at 160° for 1 h. The cycloaddition between organonitriles and sodium azide was catalyzed by indium chloride. This study shows a significant synergistic effect between the tetrazole compounds tested and trimethoprim which could be used to potentially develop new antibacterial agents.
Medicinal Chemistry (Sharjah, United Arab Emirates) published new progress about 2251-79-8. 2251-79-8 belongs to isoxazole, auxiliary class Trifluoromethyl,Fluoride,Benzene, name is 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, and the molecular formula is C8H5F3N4, COA of Formula: C8H5F3N4.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem