Chemistry is traditionally divided into organic and inorganic chemistry. Formula: C4H3NO3, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 21169-71-1
Benzylamide antagonists of protease activated receptor 2 with anti-inflammatory activity
Activation of protease activated receptor 2 (PAR2) has been implicated in inflammatory and metabolic disorders and its inhibition may yield novel therapeutics. Here, we report a series of PAR2 antagonists based on C-terminal capping of 5-isoxazolyl-l-cyclohexylalanine-l-isoleucine, with benzylamine analogues being effective new PAR2 antagonists. 5-Isoxazolyl-l-cyclohexylalanine-l-isoleucine-2-methoxybenzylamine (10) inhibited PAR2-, but not PAR1-, induced release of Ca2+(IC500.5 muM) in human colon cells, IL-6 and TNFalpha secretion (IC501-5 muM) from human kidney cells, and was anti-inflammatory in acute rat paw inflammation (ED505 mg/kg sc). These findings show that new benzylamide antagonists of PAR2 have anti-inflammatory activity.
If you are interested in 21169-71-1, you can contact me at any time and look forward to more communication. Formula: C4H3NO3
Reference£º
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem