Related Products of 638-23-3, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 638-23-3, Name is S-(Carboxymethyl)-L-cysteine, SMILES is O=C(O)[C@@H](N)CSCC(O)=O, belongs to Isoxazoles compound. In a article, author is Demina, O. V., introduce new discover of the category.
Comparison of Anti-Aggregation Activities of 5-Phenyl-3-(3-Pyridyl)Isoxazole and 5-Phenyl-3-(3-Pyridyl)-1,2,4-Oxadiazole
Two bioisosteric analogs, 5-phenyl-3-(3-pyridyl)isoxazole and 5-phenyl-3-(3-pyridyl)-1,2,4-oxadiazol, were synthesized so as to compare their antiaggregatory activities, determine the pharmacologically active fragment in the molecules of this type, and to explore the action mechanisms of the potential antiaggregatory compounds belonging to the class of 3,5-substituted isoxazoles. Antiaggregatory activities of these compounds were studied in vitro using aggregation inductors arachidonic acid, adenosine diphosphate, and adrenaline. It was shown that 5-phenyl-3-(3-pyridyl)-1,2,4-oxadiazole and 5-phenyl-3-(3-pyridyl)isoxazole completely suppressed the platelet aggregation induced by arachidonic acid and the second wave of the platelet aggregation induced by adrenaline or adenosine diphosphate. Antiaggregatory activity of substituted isoxasole was 1.1-1.5 times higher than that of substituted oxadiazole. In contrast to the isoxazole analog, 5-phenyl-3-(3-pyridyl)-1,2,4-oxadiazole at concentrations of 300-400 mu M partially suppressed the first wave of aggregation induced by adenosine diphosphate. It was demonstrated that both compounds at concentrations up to 250 mu M were not thrombin inhibitors in vitro. Thus, the introduction of nitrogen atom into the C4-position of the isoxazole ring changes the molecule properties. This suggests that the entire isoxazole and 1,2,4-oxadiazole rings belong to the pharmacophoric fragments of the molecules but not parts of the rings as it was supposed earlier.
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Reference:
Isoxazole – Wikipedia,
,Isoxazole | C3H3NO – PubChem