The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-Piperidineacetic Acid(SMILESS: OC(=O)CN1CCCCC1,cas:3235-67-4) is researched.SDS of cas: 676-96-0. The article 《Synthesis and biological evaluation of novel tyrosyl-DNA phosphodiesterase 1 inhibitors with a benzopentathiepine moiety》 in relation to this compound, is published in Bioorganic & Medicinal Chemistry. Let’s take a look at the latest research on this compound (cas:3235-67-4).
Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a promising target for antitumor therapy based on Top1 poison-mediated DNA damage. Several novel benzopentathiepines were synthesized and tested as inhibitors of TDP1 using a new oligonucleotide-based fluorescence assay. The benzopentathiepines have IC50 values in the range of 0.2-6.0 μM. According to the mol. modeling, the conformational flexibility of the dibutylamine group of the most effective inhibitor (3 d) allows it to occupy an advantageous position for effective binding compared to its cyclic counterparts. The study of cytotoxicity of these compounds revealed that all compounds cause an apoptotic cell death in MCF-7 and Hep G2 cells. Therefore the new class of very effective inhibitors of TDP1 was elaborated.
In addition to the literature in the link below, there is a lot of literature about this compound(1-Piperidineacetic Acid)Related Products of 3235-67-4, illustrating the importance and wide applicability of this compound(3235-67-4).
Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem