Cox, Robin A.; Yates, Keith published the article 《Thermodynamics of protonation of weak bases in sulfuric acid-water media, determined using the excess acidity method》. Keywords: thermodn protonation weak base; heat protonation base; entropy protonation base; nitroaniline protonation thermodn; phenylmethanol protonation thermodn; cyano compound protonation thermodn; ketone protonation thermodn; pyridine protonation thermodn; azine oxide protonation thermodn.They researched the compound: 3,5-Dimethyl-4-nitropyridine 1-oxide( cas:14248-66-9 ).Synthetic Route of C7H8N2O3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:14248-66-9) here.
The excess acidity method was used to investigate the thermodn. of the protonation process for those weak bases for which the ionization ratios (or optical densities) at several temperatures were measured in aqueous H2SO4. Standard enthalpies and entropies, at 25° in the aqueous reference state, are given for 13 primary, 1 secondary, and 2 tertiary nitroanilines, 3 cyclocompds., 13 triphenylmethanols, 3 other carbocation precursors, 2 ketones, 9 pyridines, and 9 azine N-oxides. Guidelines for estimating pKBH+ at any temperature for other weak bases are discussed.
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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem