925006-96-8,925006-96-8, Ethyl 5-(4-methoxyphenyl)isoxazole-3-carboxylate is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: To a solution of CH3CN (0.43mL, 7.32mmol) in anhydrous THF (10mL) was added 1.6M methyl lithium in diethyl ether (2.30mL, 3.66mmol) at-78C under nitrogen. The mixture was stirred at-78C for 0.5h, and ethyl 5-(4-(tert-butyl)phenyl)isoxazole-3-carboxylate 3a (500mg, 1.83mmol) in THF (10mL) was then added dropwise. The solution was stirred at-78C for 1h and then quenched with acetic acid (0.21mL, 3.66mmol). The mixture was warmed to 0C and poured onto ice/ water (10mL) and extracted with ethyl acetate (20mL). The organic lay was dried over Na2SO4, filtered and concentrated under reduced pressure. The crude residue 4a (330mg, 75%) was obtained as a white solid and directly used for next step without further purification.
As the paragraph descriping shows that 925006-96-8 is playing an increasingly important role.
Reference£º
Article; Ye, Na; Zhu, Yingmin; Liu, Zhiqing; Mei, Fang C.; Chen, Haiying; Wang, Pingyuan; Cheng, Xiaodong; Zhou, Jia; European Journal of Medicinal Chemistry; vol. 134; (2017); p. 62 – 71;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem