21169-71-1, Isoxazole-5-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of hydrochloride salt of N-{3-[4-(3-aza-bicyclo[3.1.0]hex-l-yl)-phenyl]-2-oxo- oxazolidin-5(5)-yl-methyl}-acetamide (Intermediate IV) (200 mg, 0.57 mmol), in DMF (10 mL), were added isoxazole-S-carboxylic acid (71 mg, 0.63 mmol), EDC (130 mg, 0.68 mmol), HOBt (89 mg, 0.68 mmol) and NMM (0.19 mL, 1.71 mmol) at 0 C. The reaction mixture was stirred at r.t. and progress of the reaction was monitored by TLC. On completion, DMF was evaporated in vacuo and residue was dissolved in chloroform (50 mL). The organic layer was washed with water (25 mL), brine (25 mL), dried over anhydrous sodium sulphate and concentrated in vacuo. The residue was purified by column chromatography (silica gel, 0.4: 9.6 MeOH: CHCl3) to provide the title compound (156 mg, 67%) as white solid.1H NMR (400 MHz, CDCl3): delta 0.80-0.90 (m, IH), 1.15-1.25 (m, IH), 1.85-2.02 (m, IH), 2.03 (s, 3H), 3.55-3.65 (m, IH), 3.65-3.75 (m, IH), 3.75-3.85 (m, 2H), 4.07 (t, J= 9.0 Hz, IH), 4.08- 4.20 (m, IH), 4.23 (dd, J = 9.1 and 17.6Hz, IH), 4.46 (dd, J = 9.1 and 16.9 Hz, IH), 4.70-4.85 (m, IH), 6.00-6.15 (bs, IH), 6.91 (d, J = 1.7 Hz, IH), 7.15-7.25 (m, 2H), 7.48 (d, J = 8.7 Hz, 2H), 8.33 (t, J= 1.8 Hz, IH) ESIMS (m/z): 411.3 (M+l), 21169-71-1
As the paragraph descriping shows that 21169-71-1 is playing an increasingly important role.
Reference£º
Patent; PANACEA BIOTEC LTD.; JAIN, Rajesh; TREHAN, Sanjay; DAS, Jagattaran; KAUR, Gurmeet; KANWAR, Sandeep; SINGH, Nishan; NANDA, Gurmeet Kaur; MAGADI, Sitaram Kumar; SHARMA, Sudhir Kumar; WO2010/150281; (2010); A2;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem