206055-91-6, (3-(4-Bromophenyl)isoxazol-5-yl)methanol is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step 2: Preparation of (3-(4-(4,4,5,5-tetramethvI-l,3,2-dioxaboroIan-2- vI)phenvI)isoxazoI-5-yl)methanoI (llh)(3-(4-bromophenyl)isoxazol-5-yl)methanol (300 mg, 1.18 mmol), bis(pinacolato)diboron (750 mgs 3 mol), bis(diphenylphosphino)ferrocene dichloropalladium(193 mg, 0.24 mmol), and potassium acetate (348 mg, 3.54 mmol) were added to N,N- dimethylformamide (4 mL), followed by reaction at 90 C for 2 hours. After completion of the reaction was confirmed by TLC5 the reactants were filtered through celite. The filtrate was extracted with water (20 mL) and ethyl acetate (50 mL). The organic layer was washed with water (10 mL X 2) and brine (10 mL). The organic layer was separated, dried over anhydrous magnesium sulfate, and filtered under reduced pressure to remove ethyl acetate. The residue was purified by silica gel column chromatography using ethyl acetate and hexane as a developing solvent, thus affording the title compound (3-(4-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)phenyl)isoxazol-5-yl)methanol (Hh). Yield: 60%.1U NMR(CDCl3, 400MHz): 7.88(d, 2H, J=8.0Hz), 7.79(d, 2H, J=7.6Hz), 6.58(s, IH), 4.81(s, 2H), and l.25(s, 12H)., 206055-91-6
As the paragraph descriping shows that 206055-91-6 is playing an increasingly important role.
Reference£º
Patent; DONG-A PHARM. CO., LTD.; YUHAN CO., LTD.; WO2008/108602; (2008); A1;,
Isoxazole – Wikipedia
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