14441-90-8, 5-Phenylisoxazole-3-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
into a 50-mL round-bottom flask, was placed a solution of 5- phenyl-1,2-oxazole-3-carboxylic acid (177.7 mg, 0.94 mmol, 1.00 eq.), 1-[1-[trans-3- aminocyclobutyl]- 1 H-pyrazol-3-yl]ethan- 1 -ol hydrochloride (246 mg, 1.13 mmol, 1.20 eq.),HATU (428.8 mg, 1.13 mmol, 1.20 eq.) and DIEA (363.9 mg, 2.82 mmol, 3.00 eq.) in DMF(10 mL). The resulting solution was stirred for 2 hours at room temperature. The reaction was then quenched by the addition of 20 mL of water. The resulting solution was extracted with ethyl acetate (3×20 mL) and the organic combined layers were dried over anhydrous sodium sulfate and concentrated under vacuum. The residue was applied onto a Prep-TLC with ethylacetate/petroleum ether (2:1). This resulted in 189 mg (57%) of 5 -phenyl-N-[trans-3 -[3 -(1- hydroxyethyl)- 1 H-pyrazol- 1 -yl]cyclobutyl] -1 ,2-oxazole-3 -carboxamide as a off-white solid.
As the paragraph descriping shows that 14441-90-8 is playing an increasingly important role.
Reference£º
Patent; BASTOS Cecilia M.; MUNOZ Benito; TAIT Bradley; WO2015/196071; A1; (2015);,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem