14441-90-8, 5-Phenylisoxazole-3-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
5-Phenylisoxazole-3-carboxylic acid (purchased from PharamCore, http://www.pharmacore.com; 100 mg, 0.50 mmol) and benzyl alcohol (79 mL, 0.75 mmol) were dissolved in 3 mL of acetonitrile and treated with EDC (144 mg, 0.75 mmol) and DMAP (184 mg, 1.51 mmol). The resulting solution was stirred for 12 h at room temperature. The reaction mixture was diluted with CH2Cl2, washed with 10% aqueous NaHCO3 solution (2x), water and 5% acetic acid solution (2x). The organic phase was collected, dried over Na2SO4, filtered and then concentrated in vacuo. Crude material obtained was recrystallized with hot acetonitrile to give 38 mg (27%) of 7 as a white solid. Mp 95-96oC; 1H NMR (300 MHz, CDCl3) 7.82 – 7.78 (2 H, m), 7.51-7.33 (8 H, m), 6.93 (1 H, s), 5.44 (2 H, s); 13C NMR (126 MHz, CDCl3) d 172.00, 160.06, 156.94, 135.07, 131.03, 129.35, 128.90, 128.88, 128.83, 126.78, 126.13, 100.18, 67.91. HRMS (EI), M+1 calcd. for C17H14NO3, 280.0968; found 280.1008. HPLC tR = 10.5 min.
As the paragraph descriping shows that 14441-90-8 is playing an increasingly important role.
Reference£º
Article; Moraski, Garrett C.; Markley, Lowell D.; Chang, Mayland; Cho, Sanghyun; Franzblau, Scott G.; Hwang, Chang Hwa; Boshoff, Helena; Miller, Marvin J.; Bioorganic and Medicinal Chemistry; vol. 20; 7; (2012); p. 2214 – 2220;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem