Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 14248-66-9, is researched, SMILESS is O=[N+](C1=C(C)C=[N+]([O-])C=C1C)[O-], Molecular C7H8N2O3Journal, Article, Cancer Research called Breakage of a DNA-protein complex inducd by 4-nitroquinoline 1-oxide, 4-nitropyridine 1-oxide, and their derivatives in cultured mouse fibroblasts, Author is Andoh, Toshiwo; Ide, Toshinori; Saito, Morihiko; Kawazoe, Yutaka, the main research direction is carcinogen protein DNA complex; nitroquinoline oxide DNA protein complex; nitropyridine oxide DNA protein complex.Application In Synthesis of 3,5-Dimethyl-4-nitropyridine 1-oxide.
The effects of a number of 4-nitroquinoline 1-oxide and 4-nitropyridine 1-oxide derivatives, with varying carcinogenic potencies, on the scission of proteins-DNA complexes were studied in cultured mouse fibroblasts, strain L·P3. With 22 4-nitroquinoline 1-oxide derivatives and 12 4-nitropyridine 1-oxide derivatives tested, an excellent correlation was found between the scission effect of each compound and its carcinogenicity. All carcinogens, whether strong or weak, showed pos. results in the scission test. Strong carcinogens such as 4-nitroquinoline 1-oxide (I) [56-57-5], 2-methyl-4-nitroquinoline 1-oxide [4831-62-3], 6-methyl-4-nitroquinoline 1-oxide [715-48-0], 6-chloro-4-nitroquinoline 1-oxide [3741-12-6], and 4-hydroxyaminoquinoline 1-oxide [4637-56-3] induced the scission at a low concentration of 1 × 10-5M., while weak carcinogens such as 3-methyl-4-nitroquinoline 1-oxide [14073-00-8], 6-n-butyl-4-nitroquinoline 1-oxide [21070-32-6], 6-tert-butyl-4-nitroquinoline 1-oxide [23484-01-7], 6-n-hexyl-4-nitroquinoline 1-oxide [23484-03-9], and 6-carboxy-4-nitroquinoline 1-oxide [1425-67-8] only produced the same effect at dose levels higher than 5 × 10-5M. On the other hand, some noncarcinogenic derivatives such as 8-nitroquinoline 1-oxide [14753-18-5], 4-hydroxy-quinoline 1-oxide [3039-74-5], 4-aminoquinoline 1-oxide [2508-86-3], and 6-nitroquinoline [613-50-3] could not induce the scission, while other noncarcinogens such as 3-nitroquinoline 1-oxide [7433-86-5], 5-nitroquinoline 1-oxide [7613-19-6], and 5-nitroquinoline [607-34-1] did induce scission at concentrations >1 × 10-4M. Throughout these tests the effective concentrations of active compounds were generally much lower than the concentration at which the compounds were cytotoxic; the implication of the results and the feasibility of the present method of anal. as a screening procedure for potential carcinogens and mutagens are discussed.
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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem