Zhu, Xiaolong; Li, Xuan; Li, Xuehao; Lv, Jian; Sun, Kai; Song, Xiuyan; Yang, Daoshan published the article 《Decarboxylative C-H alkylation of heteroarenes by copper catalysis》. Keywords: arylimidazopyridinyl methanamine preparation; carboxylic acid arylimidazopyridinyl decarboxylative carbon hydrogen alkylation copper catalyst; indolyl methyl arylimidazopyridine preparation; acetic acid indolyl arylimidazopyridinyl decarboxylative alkylation copper catalyst.They researched the compound: 1-Piperidineacetic Acid( cas:3235-67-4 ).HPLC of Formula: 3235-67-4. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:3235-67-4) here.
Versatile decarboxylative C-H alkylation of heteroarenes was accomplished. In the presence of Cu(OTf)2 and 4,4′-di-tert-butyl-2,2′-bipyridine, a range of heteroarenes, such as imidazo[1,2-a]pyridines, 2-phenylbenzo[d]imidazo[2,1-b]thiazole, 2-phenylindolizine and 4H-chromen-4-one, could be alkylated using diverse alkyl carboxylic acids. This developed protocol will extend the still limited number of copper catalytic decarboxylation couplings, especially in the construction of Csp2-Csp3 bonds. The developed method provided a highly attractive and alternative approach to various alkylating heteroarenes I [R1 = H, Me; R2 = H, 5-Br, 5-MeO; R3 = H, Me; R4 = 2-phenylimidazo[1,2-a]pyridin-3-yl, 2-phenylindolizin-3-yl, [2-(4-methoxyphenyl)imidazo[1,2-a]pyridin-3-yl], etc.], II [R6 = H, Me; R7 = H, Me, Ph; R6R7 = (CH2)5; R4 = 2-phenylimidazo[1,2-a]pyridin-3-yl, [2-(4-methoxyphenyl)imidazo[1,2-a]pyridin-3-yl], 7-chloro-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl, etc.] with good functional group tolerance.
There are many compounds similar to this compound(3235-67-4)HPLC of Formula: 3235-67-4. if you want to know more, you can check out my other articles. I hope it will help you,maybe you’ll find some useful information.
Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem