Deering, Robert W.; Whalen, Kristen E.; Alvarez, Ivan; Daffinee, Kathryn; Beganovic, Maya; LaPlante, Kerry L.; Kishore, Shreya; Zhao, Sijing; Cezairliyan, Brent; Yu, Shen; Rosario, Margaret; Mincer, Tracy J.; Rowley, David C. published the artcile< Identification of a bacteria-produced benzisoxazole with antibiotic activity against multi-drug resistant Acinetobacter baumannii>, HPLC of Formula: 21725-69-9, the main research area is Acinetobacter benzisoxazole antibiotic activity.
Abstract: The emergence of multi-drug resistant pathogenic bacteria represents a serious and growing threat to national healthcare systems. Most pressing is an immediate need for the development of novel antibacterial agents to treat Gram-neg. multi-drug resistant infections, including the opportunistic, hospital-derived pathogen, Acinetobacter baumannii. Herein we report a naturally occurring 1,2-benzisoxazole with min. inhibitory concentrations as low as 6.25μg ml-1 against clin. strains of multi-drug resistant A. baumannii and investigate its possible mechanisms of action. This mol. represents a new chemotype for antibacterial agents against A. baumannii and is easily accessed in two steps via de novo synthesis. In vitro testing of structural analogs suggest that the natural compound may already be optimized for activity against this pathogen. Our results demonstrate that supplementation of 4-hydroxybenzoate in minimal media was able to reverse 1,2-benzisoxazoles antibacterial effects in A. baumannii. A search of metabolic pathways involving 4-hydroxybenzoate coupled with mol. modeling studies implicates two enzymes, chorismate pyruvate-lyase and 4-hydroxybenzoate octaprenyltransferase, as promising leads for the target of 3,6-dihydroxy-1,2-benzisoxazole.
Journal of Antibioticspublished new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 21725-69-9 belongs to class isoxazole, and the molecular formula is C7H5NO2, HPLC of Formula: 21725-69-9.
Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem