Development and Validation of a First-Derivative Spectrophotometric Method for the Estimation of an Antipsychotic Drug in Pharmaceutical Formulations and Forced Degradation Studies was written by Dash, S. K.;Acharjya, S. K.;Das, P. S.;Kumar, N. K.;Patra, Ch. N.. And the article was included in Journal of Applied Spectroscopy in 2022.Formula: C23H27FN4O3 This article mentions the following:
A simple, cost-effective, and stability-indicating first-derivative spectrophotometric technique for quantifying Paliperidone in different pharmaceutical formulations is developed. In this method, the drug shows a maximum dA/dλ at 245 nm. The drug follows Beer-Lambert’s law in the concentration range 2.5-70μg/mL. Various degradation studies for the drug, such as acid hydrolysis, base hydrolysis, thermal, oxidative, and photolytic degradation are performed, and the results thereof are within the acceptable limit. The anal. method validation parameters like linearity, LOD, LOQ, precision, accuracy, etc. are conducted for the method as per the ICH Q2R(1) guideline, and the values are within the allowable range. Hence, for the determination of the Paliperidone quantity in pharmaceutical dosage forms, the developed process is a feasible one. In the experiment, the researchers used many compounds, for example, 3-(2-(4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (cas: 144598-75-4Formula: C23H27FN4O3).
3-(2-(4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (cas: 144598-75-4) belongs to isoxazole derivatives.Synthetically, isoxazoles serve as valuable precursors for the construction of diverse molecules, including many natural products. Isoxazole can be synthesised via a variety of methods. Examples include via the reaction of hydroxylamine with 1,3-diketones or derivatives of propiolic acid.Formula: C23H27FN4O3
Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem