Inhibition of L-asparagine synthetase by a new amino acid antibiotic with antitumor activity. L-(αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (NSC-163501) was written by Cooney, David A.;Jayaram, Hiremagalur N.;Ryan, Joan A.;Bono, Vincent H.. And the article was included in Cancer Chemotherapy Reports, Part 1 in 1974.Category: isoxazole This article mentions the following:
NSC-163501 (I) [42228-92-2] and its 4-hydroxy analog NSC-176324 [54549-02-9] inhibited the utilization of L-glutamine [56-85-9] by L-asparagine synthetase (EC 6.3.5.10) [37318-72-2] in mouse pancreas and tumor tissue in vivo and in vitro. Graphic anal. showed the in vitro inhibition to be competitive in nature. L-glutamine in large molar excess effectively antagonized inhibition by these agents, but dialysis experiments showed that estimated inhibition was irreversible. Attempts to show alteration of the inhibitor mol. in the act of catalysis were unsuccessful. In the experiment, the researchers used many compounds, for example, 5-Methylisoxazole (cas: 5765-44-6Category: isoxazole).
5-Methylisoxazole (cas: 5765-44-6) belongs to isoxazole derivatives. Isoxazole rings are found in some natural products, such as ibotenic acid and muscimol. The electrophilic cyclization of various 2-alkynone O-methyl oximes with a wide range of substrates such as ICl, I2, Br2, PhSeBr, etc. provides a variety of 3,4,5-trisubstituted isoxazoles in good to excellent yields.Category: isoxazole
Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem