So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Schafer, Philipp; Palacin, Thomas; Sidera, Mireia; Fletcher, Stephen P. researched the compound: 6-Chloropyridine-2-boronic Acid( cas:652148-90-8 ).Quality Control of 6-Chloropyridine-2-boronic Acid.They published the article 《Asymmetric Suzuki-Miyaura coupling of heterocycles via Rhodium-catalysed allylic arylation of racemates》 about this compound( cas:652148-90-8 ) in Nature Communications. Keywords: asym Suzuki Miyaura coupling boronic acid allylic arylation; isoanabasine preclamol niraparib anticancer agent preparation. We’ll tell you more about this compound (cas:652148-90-8).
Rhodium-catalyzed asym. Suzuki-Miyaura reaction of boronic acids with important partners including aryls, vinyls and heterocycles was reported to yield corresponding highly enantioenriched products. Further, it was showed that, Suzuki-Miyaura reaction of pyridine boronic acids were unsuitable, but they could be halogen-modified at the 2-position to undergo reaction and this halogen could then be removed or used to facilitate further reactions. The method was also used to synthesize isoanabasine, preclamol and niraparib an anticancer agent in several clin. trials. This method will be a useful tool in drug synthesis and discovery.
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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem