Chen, Xiang-jian published the artcileInfluence of parecoxib sodium pretreatment on analgesia and coagulation function in patients with chronic hepatitis B cirrhosis undergoing liver spleen operation, Quality Control of 198470-85-8, the publication is Jianyan Yixue Yu Linchuang (2016), 13(6), 757-759, database is CAplus.
Objective: To explore the influence of parecoxib sodium pretreatment on analgesia and coagulation function in the patients with chronic hepatitis B cirrhosis undergoing liver spleen operation. Methods: A total of 100 cases of chronic hepatitis B cirrhosis undergoing splenectomy in our hospital from Jan. 2012 to Feb. 2015 were selected and divided into the research group (n = 50) and control group (n = 50). The research group was given 40 mg of parecoxib sodium by i.v. injection at 10 min before anesthesia, while the control group was i.v. injected with 4 mL normal saline at 10 min before anesthesia. Then the pump pressing times during sufentanil self-control vein analgesia, use amount of sufentanil, adverse reactions at postoperative 24 h, and thrombin time (TT), prothrombin time (PT), platelet (PLT) count and fibrinogen(FIB) levels at different postoperative time points were compared between the two group. Results: The pump pressing times within postoperative 24 h during sufentanil self-control vein analgesia in the research group was less than that in the control group, and the difference was statistically significant (t = 5.0, P < 0.001). TT, PT, PLT count and fibrinogen had no statistical differences between the two groups (P > 0.05). Conclusion: Parecoxib sodium can decrease the dosage of analgesic drugs in the patients with chronic hepatitis B cirrhosis undergoing spleen operation, moreover without affecting the coagulant function.
Jianyan Yixue Yu Linchuang published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Quality Control of 198470-85-8.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
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