Chen, Lin’s team published research in Shandong Yiyao in 55 | CAS: 198470-85-8

Shandong Yiyao published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Chen, Lin published the artcileObservation on preemptive analgesic effect of parecoxib sodium and dezocine during orthopedic surgery, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Shandong Yiyao (2015), 55(5), 49-51, database is CAplus.

One hundred and twenty patients with tibiofibula fracture receiving surgery of open reduction internal fixation were randomly divided into four groups, 30 patients in each. At 20 min before skin incision after anesthesia induction, the C group received 5 mL normal saline by i.v. injection, the P group received 40 mg parecoxib sodium by i.v. injection, the D group received 0.1 mg/kg dezocine by i.v. injection, and the PD group received 40 mg parecoxib sodium and 0.1 mg/kg dezocine by i.v. injection. The recovery time, consciousness recovery time, extubation time and Riker sedation agitation scale (SAS) at 10 min after extubation were recorded. The static and dynamic VAS score, mean arterial pressure (MAP), heart rate (HR) and SpO2 at 1, 2, 4, 12 and 24 h after surgery were recorded, as well as the times of pressing analgesia pump within 24 h after surgery. There was no statistical difference in recovery time, extubation time, consciousness recovery time, MAP, HR, SpO2 or the times of pressing analgesia pump within 24 h after surgery among the four groups (P > 0.05). Compared with the C group, the Riker SAS score decreased in the PD group (P < 0.05). Compared with the P and D groups, the static and dynamic VAS score at 1, 2 and 12 h after surgery decreased (P < 0.05). The combination of parecoxib sodium and dezocine for preemptive analgesia in the surgery of open reduction internal fixation was superior to parecoxib sodium or dezocine alone.

Shandong Yiyao published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem