Chen, Jiang published the artcileInfluence of flurbiprofen and parecoxib sodium on behavior and spinal cord COX-2 expression in incision pain rats, Category: isoxazole, the publication is Zhongguo Yaowu Yu Linchuang (2014), 14(5), 600-601, database is CAplus.
Forty-eight SD rats were randomly divided into control group, 0.9% NaCl group, flurbiprofen group (0.9 mg/100 g) and parecoxib sodium group (0.6 mg/100 g). Behavior and pain score were observed COX-2 expression was determined by ELISA. Pain score and COX-2 expression of flurbiprofen group and parecoxib sodium group were significantly lower than those in NaCl group (P<0.05). And no significant difference of Pain score and COX-2 expression was found between flurbiprofen group and parecoxib sodium group (P>0.05). Flurbiprofen and parecoxib sodium both inhibits COX-2 expression in spinal cord and showed analgesic effect in incision pain rats.
Zhongguo Yaowu Yu Linchuang published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Category: isoxazole.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem