Capreti, Naylil M. R.’s team published research in Organic Letters in 17 | CAS: 1076-59-1

Organic Letters published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C9H7NO2, Application of 3-Phenylisoxazol-5(2H)-one.

Capreti, Naylil M. R. published the artcileMichael Addition of Soft Carbon Nucleophiles to Alkylidene Isoxazol-5-ones: A Divergent Entry to β-Branched Carbonyl Compounds, Application of 3-Phenylisoxazol-5(2H)-one, the publication is Organic Letters (2015), 17(10), 2490-2493, database is CAplus and MEDLINE.

A novel, divergent strategy toward the synthesis of β-branched (and linear) carbonyl compounds is developed by taking advantage of alkylidene isoxazol-5-ones as key building blocks. The yields obtained range from good to excellent, therefore making the described methods attractive options for building such mols. E.g., reaction of alkylidene isoxazol-5-one (I) with TMSOCPh:CH2, catalyzed by Sc(OTf)3, gave 90% II. Treatment of II with Fe(SO4) and NaNO2 gave 83% PhCCCHPhCH2COPh.

Organic Letters published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C9H7NO2, Application of 3-Phenylisoxazol-5(2H)-one.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem