42831-50-5, 5-Methylisoxazole-4-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step A 5-Methyl-isoxazole-4-carboxylic acid [2-(4-methoxy-phenylamino)-phenyl]-amide To N-(4-methoxy-phenyl)-benzene-1,2-diamine di-hydrochloride salt (0.942 g, 3.28 mmol), 5-methyl-isoxazole-4-carboxylic acid (0.500 g, 3.93 mmol), Et3N (4.6 ml, 32.8 mmol) and DMAP. (cat.) in CH2Cl2 (10 ml) was added PPAA as a 50% solution in EtOAc (3.0 ml, 4.92 mmol). The reaction was stirred at room temperature overnight, diluted with EtOAc (100 ml) and washed with sat. NaHCO3 (2*30 ml) and brine (1*30 ml), dried (MgSO4), filtered and concentrated by vacuum. The resultant oil was subjected to flash chromatography (SiO2, biotage, 25% EtOAc/hexanes) to give 5-methyl-isoxazole-4-carboxylic acid [2-(4-methoxy-phenylamino)-phenyl]-amide as an oil (0.729 g, 2.26 mmol, 69%). MS 324 (M+1).
42831-50-5, The synthetic route of 42831-50-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Chesworth, Richard; Gegnas, Laura D.; US2004/2524; (2004); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem