Brief introduction of 3405-77-4

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Recommanded Product: 3405-77-4, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 3405-77-4

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Recommanded Product: 3405-77-4, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 3405-77-4, Name is 5-Methylisoxazole-3-carboxylic acid, molecular formula is C5H5NO3

Searching for new cures for tuberculosis: Design, synthesis, and biological evaluation of 2-methylbenzothiazoles

The actual development and clinical use of new therapeutics for tuberculosis (TB) have remained stagnant for years because of the complexity of the disease process, the treatment of which at present requires the administration of drug combinations over a 6month period. There is thus an urgent need for the discovery and development of novel, more active, and less toxic anti-TB agents. In this study, we report on the chemistry and biology of a series of potent 5-(2-methylbenzothiazol-5-yloxymethyl) isoxazole-3-carboxamide derivatives, which proved to be active against replicating Mycobacterium tuberculosis (Mtb) H37Rv. The most potent compounds 7j and 7s were found to inhibit Mtb growth at micromolar concentrations, with MICvalues of 1.4 and 1.9 muM, respectively. Impressively, all active compounds were nontoxic toward Vero cells (IC50 > 128 muM). Moreover, the best of these compounds were also tested against protozoan parasites, and some of these compounds were found to show activity, especially against Plasmodium falciparum. These studies thus suggest that certain 2-methylbenzothiazole based compounds may serve as promising lead scaffolds for further elaboration as anti-TB drugs and as possible antimalaria drugs. 2009 American Chemical Society.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Recommanded Product: 3405-77-4, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 3405-77-4

Reference£º
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem