3405-77-4, 5-Methylisoxazole-3-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: N-protected-amino acid-OH or N-protected-peptide-OH (1?equiv) was dissolved in ? THF and cooled to??15?¡ãC. To the stirred solution, ? N-methylmorpholine (NMM) (1?equiv) and ? isobutylchloroformate (1?equiv) were added consecutively. After precipitation of ? N-methylmorpholine hydrochloride, the amine (1?equiv) was added and the mixture was allowed to warm to 25?¡ãC within 30?min. It was stirred for additional 90?min, and the solvent was removed under reduced pressure. The residue was dissolved in EtOAc and the solution was washed with H2O, saturated NaHCO3, 5percent citric acid and brine. The solvent was dried (MgSO4) and evaporated. The crude residue was purified by flash column chromatography to give the product.
3405-77-4, The synthetic route of 3405-77-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Chuck, Chi-Pang; Chen, Chao; Ke, Zhihai; Chi-Cheong Wan, David; Chow, Hak-Fun; Wong, Kam-Bo; European Journal of Medicinal Chemistry; vol. 59; (2013); p. 1 – 6;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem