The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-Piperidineacetic Acid(SMILESS: OC(=O)CN1CCCCC1,cas:3235-67-4) is researched.Related Products of 1445085-77-7. The article 《On the cleavage of N-C linkage of piperidine N-derivatives by mouse and rat liver enzyme system》 in relation to this compound, is published in Yakugaku Zasshi. Let’s take a look at the latest research on this compound (cas:3235-67-4).
The cleavage of the N-C bond of piperidine derivatives by the 9000 × g supernatant of rat liver was more readily carried out than that by the supernatant of mouse liver. The cleavage of N-Et derivatives such as N-methylpiperidine (I) [626-67-5] and N-ethylpiperidine [766-09-6] was not readily carried out by these supernatants, whereas that of the Mannich bases was done readily. The addition of phenobarbital accelerated N-C bond cleavage, but 3-methylcholanthrene was without effect. Pretreatment of the animals with SKF-525A inhibited the cleavage.
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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem