288-14-2, Name is Isoxazole, belongs to Isoxazoles compound, is a common compound. 288-14-2In an article, authors is Abdellatif, Khaled R.A., once mentioned the new application about 288-14-2.
New 1,2-diaryl-4-substituted-benzylidene-5-4H-imidazolone derivatives: Design, synthesis and biological evaluation as potential anti-inflammatory and analgesic agents
A new series of 1,2-diaryl-4-substituted-benzylidene-5-4H-imidazolone derivatives 10a-h was designed and synthesized for evaluation as selective COX-2 inhibitors, anti-inflammatory agents and as analgesic agents. All compounds were more selective for COX-2 isozyme and showed good in vivo anti-inflammatory activity. Compounds 10a, 10b, 10e and 10f were the most COX-2 selective compounds (S.I.?=?10.76, 10.87, 8.69 and 9.14 respectively), the most potent anti-inflammatory derivatives (ED50?=?65.7, 60.2, 76.3 and 107.4?mumol/kg respectively) in comparison with Celecoxib (COX-2 S.I.?=?8.61, ED50?=?82.2?mumol/kg) and were less ulcerogenic (ulcer indexes?=?1.22?3.02) than Ibuprofen (ulcer index?=?20.25) and comparable to Celecoxib (ulcer index?=?2.93). The four derivatives (10a, 10b, 10e and 10f) showed considerable analgesic activities which are clearly parallel to their anti-inflammatory activities.
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Reference£º
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem