13999-39-8, The synthetic route of 13999-39-8 has been constantly updated, and we look forward to future research findings.
13999-39-8, 3-Amino-4,5-dimethylisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
STEP07: Synthesis of 5-methyl-thiophene-2-sulphonic acid (4, 5-dimethyl-isoxazol-3yl) amide.; The solution of 5-Methyl thiophene-2-sulphonyl chloride (10.5 gm, 0.053 mol) in (15ml) methylene chloride was added to the solution of 3-amino-4, 5-dimethylisoxazole (4 gm, 0.035 mol) and dimethylaminopyridine (500 mg) in pyridine (20 ml) at 0 C. After the completion of the addition the temperature of the reaction mixture was slowly raised to room temperature and stirred for 6 hours. The reaction mixture was then concentrated under vacuum, the residue thus obtained was acidified using IN hydrochloric acid followed by extraction with methylene chloride (100 ml x2). The combined extracts were washed with water and brine solution. Organic layer was then dried over sodium sulphate and concentrated to give 4.0 gm of 5-methyl-thiophene-2-sulphonic acid (4, 5-dimethyl- isoxazol-3yl) amide as brown colored solid.; STEP09: Synthesis of 5-methyl-thiophene-2-sulphonic acid (4, 5-dimethyl-isoxazol-3yl) amide.; The solution of 5-Methyl thiophene-2-sulphonyl chloride (10.5 gm, 0.053 mol) in (15ml) methylene chloride was added to the solution of 3-amino-4, 5-dimethylisoxazole (4 gm, 0.035 mol) and dimethylaminopyridine (500 mg) in pyridine (20 ml) at 0 C. After the completion of the addition the temperature of the reaction mixture was slowly raised to s room temperature and stirred for 6 hours. The reaction mixture was then concentrated under vacuum, the residue thus obtained was acidified using IN hydrochloric acid followed by extraction with methylene chloride (100 ml x2). The combined extracts were washed with water and brine solution. Organic layer was then dried over sodium sulphate and concentrated to give 4.0 gm of 5-methyl-thiophene-2-sulphonic acid (4, 5-dimethyl- o isoxazol-3yl) amide as brown colored solid.; STEP05: Synthesis of 5-methyl-thiophene-2-sulphonic acid (4, 5-dimethyl-isoxazol-3yl) amide.; The solution of 5-Methyl thiophene-2-sulphonyl chloride (10.5 gm, 0.053 mol) in (15ml) methylene chloride was added to the solution of 3-amino-4, 5-dimethylisoxazole (4 gm, 0.035 mol) and dimethylaminopyridine (500 mg) in pyridine (20 ml) at 0 C. After the completion of the addition the temperature of the reaction mixture was slowly raised to room temperature and stirred for 6 hours. The reaction mixture was then concentrated under vacuum, the residue thus obtained was acidified using IN hydrochloric acid followed by extraction with methylene chloride (100 ml x2). The combined extracts were washed with water and brine solution. Organic layer was then dried over sodium sulphate and concentrated to give 4.0 gm of 5-methyl-thiophene-2-sulphonic acid (4, 5-dimethyl- isoxazol-3yl) amide as brown colored solid.; STEPIl: Synthesis of 5-methyl-thiophene-2-sulphonic acid (4, 5-dimethyl-isoxazol-3yl) amide.; The solution of 5-Methyl thiophene-2-sulphonyl chloride (l.Ogm, 0.081mol) in (25ml) methylene chloride was added to the solution of 3-amino-4, 5-dimethylisoxazole (6.2gm, 0.055mol ) and dimethylaminopyridine (500 mg) in pyridine (40 ml) at 0 C. After the completion of the addition the temperature of the reaction mixture was slowly raised to room temperature and stirred it for 6 hours. The reaction mixture was then concentrated under vacuum, the residue thus obtained was acidified using IN hydrochloric acid followed by extraction with methylene chloride (100 ml x2). The combined extracts were washed with water and brine solution. Organic layer was then dried over sodium sulphate and concentrated to give 18 gm of 5-methyl-thiophene-2-sulphonic acid (4, 5-dimethyl- isoxazol-3yl) amide as brown colored solid.; STEP05: Synthesis of 5-methyl-thiophene-2-sulphonic acid (4, 5-dimethyl-isoxazol-3yl) amide.; The solution of 5-Methyl thiophene-2-sulphonyl chloride (16.0gm, 0.08 lmol) in (25ml) methylene chloride was added to the solution of 3-amino-4, 5-dimethylisoxazole (6.2gm, 0.055mol ) and dimethylaminopyridine (500 mg) in pyridine (40 ml) at 0 C. After the completion of the addition the temperature of the reaction mixture was slowly raised to room temperature and stirred it for 6 hours. The reaction mixture was then concentrated under vacuum, the residue thus obtained was acidified using IN hydrochloric acid followed by extraction with methylene chloride (100 ml x2). The combined extracts were washed with water and brine solution. Organic layer was then dried over sodium sulphate and concentrated to give 18 gm of 5-methyl-thiophene-2-sulphonic acid (4, 5-dimethyl- isoxazol-3yl) amide as brown colored solid.; STEP05: Synthesis of 5-methyl-thiophene-2-sulphonic acid (4, 5-dimethgammal-isoxazol-3yl) amide.; The solution of 5-Methyl thiophene-2-sulphonyl chloride (l.Ogm, 0.08 lmol) in (25ml) methylene chloride was added to the solution of 3-amino-4, 5-dimethylisoxazole (6.2gm, 0.055mol ) and dimethylaminopyridine (500 mg) in pyridine (40 ml) at 0 C. After the completion of the addition the temperature of the reaction mi…
13999-39-8, The synthetic route of 13999-39-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; TORRENT PHARMACEUTICALS LTD; WO2007/100295; (2007); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem