123770-62-7, Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate (50.0 mg, 0.29 mmol) in DCM (2 mL) was added diethylaminosulfur trifluoride (70.6 mg, 0.06 ml, 0.44 mmol). The mixture was stirred at 40 C for 1 hour. Water (3 mL) was added and the mixture was extracted with ethyl acetate (5 mLchi3). The combined organic layers were washed with brine (5 mL), dried over Na2S04and concentrated. The crude mixture was purified by flash chromatography with heptane:ethyl acetate = 1 :0 to 0:1 to give ethyl 5- (fluoromethyl)isoxazole-3-carboxylate (41 .0 mg).
123770-62-7, The synthetic route of 123770-62-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; H. LUNDBECK A/S; KEHLER, Jan; JUHL, Karsten; MARIGO, Mauro; VITAL, Paulo, Jorge, Vieira; JESSING, Mikkel; LANGGARD, Morten; RASMUSSEN, Lars, Kyhn; CLEMENTSON, Carl, Martin, Sebastian; (270 pag.)WO2018/7249; (2018); A1;,
Isoxazole – Wikipedia
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