Phosphate binder for dialysis patients was written by Becker, Conny;Gensthaler, Brigitte M.;Grafe, Kerstin A.;Morck, Hartmut. And the article was included in Pharmazeutische Zeitung in 2007.Application In Synthesis of Sodium (4-chloro-3-methylisoxazol-5-yl)((2-(2-(6-methylbenzo[d][1,3]dioxol-5-yl)acetyl)thiophen-3-yl)sulfonyl)amide This article mentions the following:
Characteristics, pharmacodynamics, and pharmacokinetics are discussed of a new Ca-free phosphate binder, lanthanum carbonate (Fosrenol), for dialysis patients with terminal nephrotic insufficiency to avoid hyperphosphatemia. 4 New drugs are characterized: oxytocin analog carbetocin (Pabal), Tyr kinase inhibitor dasatinib (Sprycel), cyclooxygenase (COX)-2 inhibitor lumiracoxib (Prexige), and endothelin-A-receptor inhibitor sitaxentan (Thelin). In the experiment, the researchers used many compounds, for example, Sodium (4-chloro-3-methylisoxazol-5-yl)((2-(2-(6-methylbenzo[d][1,3]dioxol-5-yl)acetyl)thiophen-3-yl)sulfonyl)amide (cas: 210421-74-2Application In Synthesis of Sodium (4-chloro-3-methylisoxazol-5-yl)((2-(2-(6-methylbenzo[d][1,3]dioxol-5-yl)acetyl)thiophen-3-yl)sulfonyl)amide).
Sodium (4-chloro-3-methylisoxazol-5-yl)((2-(2-(6-methylbenzo[d][1,3]dioxol-5-yl)acetyl)thiophen-3-yl)sulfonyl)amide (cas: 210421-74-2) belongs to isoxazole derivatives. An isoxazolyl group is found in many beta-lactamase-resistant antibiotics, such as cloxacillin, dicloxacillin and flucloxacillin. As with isoxazolines, isoxazoles may be cleaved using low-valent titanium obtained from the Kulinkovich reaction.This procedure affords enaminoketones from 2,4-substituted isoxazoles.Application In Synthesis of Sodium (4-chloro-3-methylisoxazol-5-yl)((2-(2-(6-methylbenzo[d][1,3]dioxol-5-yl)acetyl)thiophen-3-yl)sulfonyl)amide
Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem