Reference of 2-Chloropyridine 1-oxide. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Chloropyridine 1-oxide, is researched, Molecular C5H4ClNO, CAS is 2402-95-1, about Research on synthesis of 2-chloro-4-nitropyridine-N-oxide. Author is Li, Quanliang; Wang, Jun; Li, Shujing.
2-Chloro-4-nitropyridine-N-oxide was synthesized from 2-chloropyridine by N-oxidation and mixed acid nitrifying with one pot reaction. The intermediate yield of 2-chloropyridine-N-oxide was 96.5% when n(2-chloropyridine):n(H2O2):n(CH3COOH) = 1:3.5:1.5, the reaction temperature was 80°C and the reaction time was 3 h. Synthetic liquid proceeded nitration reaction directly after enrichment. The production yield of 2-chloro-4-nitropyridine-N-oxide was 85.8% when n(2-chloropyridine-N-oxide):n(HNO3) = 1:3.5, V(H2SO4)/V(HNO3) = 1:1, the reaction temperature was 80°C and the reaction time was 6 h. The structures of intermediate and target product were confirmed by M.p., IR, MS and elemental anal. The final product was gained.
In addition to the literature in the link below, there is a lot of literature about this compound(2-Chloropyridine 1-oxide)Reference of 2-Chloropyridine 1-oxide, illustrating the importance and wide applicability of this compound(2402-95-1).
Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem