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A mild method for the aminolysis of lactones with aminoheterocycles in the presence of magnesium ethoxide is described. A wide range of electronically diverse aminoheterocycles and substituted lactones successfully participate in this transformation to furnish the resulting amido-alcohol products. Further application of this method to the synthesis of chiral alpha-amino amides derivatives is also described.

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Reference：
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem