59669-59-9, Name is 3-(tert-Butyl)isoxazol-5-amine, belongs to isoxazole compound, is a common compound. Recommanded Product: 3-(tert-Butyl)isoxazol-5-amineIn an article, once mentioned the new application about 59669-59-9.
Trk receptors play a key role in the development and maintenance of neuronal networks. Recent evidence suggests that the Trk family, specifically TrkA, is an important driver for tumour growth, inflammatory and neuropathic pain, and chemoresistance. Through a computational screen, a novel Trk active pharmacophore was identified and a series of pyrazine-based inhibitors were developed, which potently inhibited TrkA. Inhibitors displayed the highest activity on TrkA when screened against a small, tyrosine kinase panel and also exhibited a non-linear SAR. Predicted binding modes of the inhibitors were examined, which identified exploitable regions for future development of more advanced inhibitors. This journal is
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Reference：
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem