Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-Piperidineacetic Acid, is researched, Molecular C7H13NO2, CAS is 3235-67-4, about Intramolecular easily polarizable hydrogen bonds with 1-piperidine carboxylic acids.HPLC of Formula: 3235-67-4.
IR spectra were plotted for (C5H10N)(CH2)nCOOH (n = 1-4) in CDCl3 solutions From the carboxylic bands, information is obtained on whether the proton is present at the carboxylic group or at the N atom. Furthermore, an IR continuum indicates the presence of easily-polarizable H bonds. With 1-piperidineacetic acid, the proton is found at the N atom. Intermol. asym. O-…H+N H bonds are formed, which are not easily polarizable. When n = 2-4, intramol. OH…N ⇄ O-…H+N bonds are found with the proton distributed between the O and N atoms. A double min. energy surface is present in these bonds. A strong IR continuum indicates that these H bonds are easily polarizable. With increasing concentration, the weight of the polar proton boundary structure O-…H+N increases due to interaction effects between these H bonds. These interaction effects do not occur when n = 4, as they are hindered by the hydrocarbon skeleton. In the case of intermol. OH…N ⇄ O-…H+N bonds, the IR continuums show structures in the 3200-1800 cm-1 region. These structures are not observed with the intramol. bonds, as these are shorter. Addition of water causes dissociation of the intramol. OH…N ⇄ O-…H+N H bonds.
In addition to the literature in the link below, there is a lot of literature about this compound(1-Piperidineacetic Acid)HPLC of Formula: 3235-67-4, illustrating the importance and wide applicability of this compound(3235-67-4).
Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem