Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 199327-61-2, Name is 7-Methoxy-6-(3-morpholinopropoxy)quinazolin-4(3H)-one, molecular formula is , belongs to Isoxazoles compound. In a document, author is Thiriveedhi, Arunkumar, Product Details of 199327-61-2.
Novel Hybrid Molecules of Isoxazole Chalcone Derivatives: Synthesis and Study of In Vitro Cytotoxic Activities
Background: Now-a-days, the model of hybrid drugs has acquired recognition in medicine due to their significant role in the treatment of different health problems. Methods: We have synthesized new series of isoxazole-chalcone conjugates (14a-m) by the Claisen-Schmidt condensation of suitable substituted acetophenones with isoxazole aldehydes (12a-d). In vitro cytotoxic activity of the synthesized compounds was studied against four different selected human cancer cell lines by using sulforhodamine B (SRB) method. Results: The adopted scheme resulted in good yields of new series of isoxazole-chalcone conjugates (14a-m). Potent cytotoxic activity was observed for compounds -14a, 14b, 14e, 14i, 14j and 14k against prostate DU-145 cancer cell line. Conclusion: The observed potent cytotoxic activities were due to the presence of 3,4,5-trimethoxyphenyl group.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 199327-61-2, in my other articles. Product Details of 199327-61-2.
Reference:
Isoxazole – Wikipedia,
,Isoxazole | C3H3NO – PubChem